Systembiologie der Hämatopoese und hämatopoetischer Neoplasien

gefördert durch: Bundesministerium für Bildung und Forschung




I. Glauche, K. Moore, L. Thielecke, K. Horn, M. Loeffler and I. Roeder (2009)

Stem Cell Proliferation and Quiescence—Two Sides of the Same Coin

PLoS Computational Biology, 2009 July; 5(7)  zum Abstract




N. Grund, P. Maier, F.A. Giordano, J.U. Appelt, M. Zucknick, L. Li, F. Wenz, W.J. Zeller, S. Fruehauf, H. Allgayer, and S. Laufs. (2010)

Analysis of self-inactivating lentiviral vector integration sites and flanking gene expression in human peripheral blood progenitor cells after alkylator chemotherapy

Human Gene Therapy. August 2010, 21(8): 943-956. zum Abstract


B. Klaus and K. Strimmer (2010)

Thresholding methods for feature selection in genomics: higher criticism versus false non-discovery rates. Proceedings of the 7th International Workshop on Computational Systems Biology

WCSB 2010 (June 16-18, 2010, Luxembourg), pp. 59-62.


J. Läuter and M. Rosolowski (2010)

Testing for sphericity instead of testing for null means in multivariate analysis - a new and very effective principle.

Proceedings of the Second joint statistical meeting Deutsche Arbeitsgemeinschaft Statistik

Statistics under one umbrella 56. Biometrisches Kolloquium (March 23_26, 2010, Technische Universität Dortmund)


M. Scholz, A. Gross, M. Loeffler (2010)

A biomathematical model of human thrombopoiesis under chemotherapy.

J Theor Biol, 2010, 264(2), 287-300 zum Abstract




A. Ehninger, A. Trumpp (2011)

The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in.

J Exp Med. 2011 Mar 14;208(3):421-8. zum Abstract


F.A. Giordano, U.R. Sorg, J.U. Appelt, N. Lachmann, S. Bleier, I. Roeder, V. Kleff, M. Flasshove, W.J. Zeller, H. Allgayer, C.V. Kalle, S. Fruehauf, T. Moritz and S. Laufs. (2011)

Clonal inventory screens uncover monoclonality following serial transplantation of MGMTP140K transduced stem cells and dose-intense chemotherapy.

Hum Gene Ther. 2011 Jun;22(6):697-710.  zum Abstract


I. Glauche, I. Roeder (2011)

Heterogeneity and flexibility of stem cell fate decisions - A conceptual perspective.

Book chapter in: Stem Cells - From Mechanisms to Technologies, edited by Michal K. Stachowiak and Emmanuel S Tzanakakis, World Scientific Publishing Co. 2011, pp. 31-62


I. Glauche, L. Thielecke, I. Roeder (2011)

Cellular aging leads to functional heterogeneity of hematopoietic stem cells: a modelling perspective.

Aging Cell, 2011, Jun;10(3):457-65  zum Abstract


D. Heckmann, S. Laufs, P. Maier, M. Zucknick, F.A. Giordano, M.R. Veldwijk, V. Eckstein, F. Wenz, W.J. Zeller, S. Fruehauf, H. Allgayer (2011)

A Lentiviral CXCR4 overexpression and knockdown model in colorectal cancer cell lines reveals plerixafor-dependent suppression of SDF-1α-induced migration and invasion.

Onkologie. 2011;34(10):502-8.   zum Abstract


T. Herold, V. Jurinovic, M. Mulaw, T. Seiler, A. Dufour, S. Schneider, P.M. Kakadia, M. Feuring- Buske, J. Braess, K. Spiekermann, U. Mansmann, W. Hiddemann, C. Buske and S.K. Bohlander (2011)

Expression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20.

Genes, Chromosomes and Cancer, 2011 Jul;50(7):546-58.  zum Abstract


T. Herold, V. Jurinovic, K.H. Metzeler, A.L. Boulesteix, M. Bergmann, T. Seiler, M. Mulaw, S. Thoene, A. Dufour, Z. Pasalic, M. Schmidberger, M. Schmidt, S. Schneider, P.M. Kakadia, M. Feuring-Buske, J. Braess, K. Spiekermann, U. Mansmann, W. Hiddemann, C. Buske, S.K. Bohlander (2011)

An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia.

Leukemia. 2011 Oct;25(10):1639-45.  zum Abstract


A. Herrmann, A. Haake, O. Ammerpohl, I. Martin-Guerrero, K. Szafranski, K. Stemshorn, M. Nothnagel, S.K. Kotsopoulos, J. Richter, J. Warner, J. Olson, D. R. Link, S. Schreiber, M. Krawczak, M. Platzer, P. Nürnberg, R. Siebert, J. Hampe (2011)

Pipeline for Large-Scale Microdroplet Bisulfite PCR-Based Sequencing Allows the Tracking of Hepitype Evolution in Tumors.

PLoS One 2011;6(7):e21332.  zum Abstract


Bonzheim I, Salaverria I, Haake A, Gastl G, Adam P, Siebert R, Fend F, Quintanilla-Martinez L. (2011)

A unique case of follicular lymphoma provides insights to the clonal evolution from follicular lymphoma in situ to manifest follicular lymphoma.

Blood. 2011 Sep 22;118(12):3442-4.  zum Abstract


B. Klaus and K. Strimmer (2011)

Learning false discovery rates by fitting sigmoidal threshold functions.

Journal de la Societe Francaise de Statistique – Vol. 152 No. 2 39-50.  zum Abstract


I. Kurth, K. Franke, T. Pompe, M. Bornhäuser and C. Werner (2011)

Extracellular Matrix Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate.

Macromol Biosci., 2011 Feb 21.  zum Abstract


M. Maneck, A. Schrader, D. Kube, R. Spang (2011)

Genomic data integration using guided clustering.

Bioinformatics. 2011 Aug 15;27(16):2231-8. zum Abstract


U. Mansmann and V. Jurinovic. (2011)

Biological feature validation of estimated gene interaction networks from microarray data: a case study on MYC in lymphomas.

Briefings in Bioinformatics, 2011 May;12(3):230-44.  zum Abstract


I. Roeder, M. Loeffler, I. Glauche (2011)

Towards a quantitative understanding of stem cell-niche in- teraction: experiments, models, and technologies.

Blood Cells Mol Dis. 2011;46: 308-317. zum Abstract


I. Salaverria and R. Siebert. (2011)

The Gray Zone Between Burkitt's Lymphoma and Diffuse Large B-Cell Lymphoma From a Genetics Perspective.

J Clin Oncol., 2011 May;29 (14);1835-1843.  zum Abstract


I. Salaverria and R. Siebert. (2011)

Follicular Lymphoma grade 3B.

Best practice & Research Clinical Haematology. 2011 Jun;24(2):111-9  zum Abstract


M. Scholz, A. Engert, J. Franklin, A. Josting, V. Diehl, D. Hasenclever, M. Loeffler; German Hodgkin's Lymphoma Study Group. (2011)

Impact of first and second line treatment for Hodgkin’s lymphoma on the incidence of AML/MDS and NHL – Experience of the German Hodgkin’s Lymphoma Study Group analysed by a parametric model of carcinogenesis.

Ann Oncol. 2011 Mar;22(3):681-8.  zum Abstract


M. Tesio, A. Trumpp (2011)

Breaking the cell cycle of HSCs by p57 and friends.

Cell Stem Cell. Sep 2;9(3):187-92. zum Abstract


V. Zuber and K. Strimmer (2011)

High-Dimensional Regression and Variable Selection Using CAR Scores.

Statistical Applications in Genetics and Molecular Biology: Vol.10: Iss. 1, Article 34.


A. Knechtel (2011)

Mathematische Modellierung der Wachstumsdynamiken therapieresistenter Zellklone in Patienten mit chronischer myeloischer Leukämie (CML), Diplomarbeit, HTWK Leipzig


K. Franke

Adhesion and Single Cell Tracking of Hematopoietic Stem Cells on Extracellular Matrices.

Dissertation 2011; Technische Universität Dresden


M. Wetzler

Simulationsmodell der menschlichen Granulopoese.

Dissertation 2011; Universität Leipzig




I. Glauche, K. Horn, M. Horn, L. Thielecke, M.A. Essers, A. Trumpp, I. Roeder (2012)

Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations

Br J Cancer. 2012 May 22;106(11):1742-52. doi: 10.1038/bjc.2012.142   zum Abstract


J. Laeuter, M. Rosolowski, E. Glimm (2012)

Exact multivariate tests – a new effective principle of controlled model choice.

2012, arXiv:1202.2045v1


M. Prewitz, F.P. Seib, T. Pompe, C. Werner (2012)

Polymeric Biomaterials for Stem Cell Bioengineering

Macromol Rapid Commun. 2012 Sep 14;33(17):1420-31.   zum Abstract


N. Scherf, K. Franke, I. Glauche, I. Kurth, M. Bornhäuser, C. Werner, T. Pompe, I. Roeder (2012)

On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

Exp Hematol. Exp Hematol. 2012 Feb;40(2):119-30.e9.   zum Abstract


N. Scherf, C. Ludborzs, K. Thierbach, J.P. Kuska, U.-D. Braumann, P. Scheibe, T. Pompe, I. Glauche, I. Roeder (2012)

FluidTracks - Combining Nonlinear Image Registration and Active Contours for Cell Tracking

Book chapter in: T. Tolxdorff, T. M. Deserno, H. Handels, H.-P. Meinzer (Hrsg.): Bildverarbeitung für die Medizin 2012 - Algorithmen, Systeme, Anwendungen. Informatik aktuell. Springer-Verlag, pp. 57-62, März 2012.


N. Scherf, M. Herberg, K. Thierbach, T. Zerjatke, T. Kalkan, P. Humphreys, A. Smith, I. Glauche, I. Roeder (2012)

Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions.

Bioinformatics, 28: i556-i561 zum Abstract


M. Scholz, S. Schirm, M. Wetzler, C. Engel, M. Loeffler (2012)

Pharmacokinetic and –dynamic modelling of G-CSF derivatives in humans

Theor Biol Med Model. 2012 Jul 30;9(1):32.  zum Abstract


A. Schrader, S. Bentink, R. Spang, D. Lenze, M. Hummel, M. Kuo, J.R. Arrand, P.G. Murray, L. Trümper, D. Kube, M. Vockerodt (2012)

High myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas.

Int J Cancer. 2012 Aug 15;131(4):E348-61.   zum Abstract


A. Schrader, K. Meyer, F. von Bonin, M. Vockerodt, N. Walther, E. Hand, A. Ulrich, K. Matulewicz, D. Lenze, M. Hummel, A. Kieser, M. Engelke, L. Trümper and D. Kube (2012)

Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Cell Communication and Signaling 2012 Dec 20;10(1):43.   zum Abstract


S. Tschiedel, E. Bach, A. Jilo, S.Y. Wang, T. Lange, H.K. Al-Ali, V. Vucinic, D. Niederwieser, M. Cross (2012)

Bcr-Abl dependent post-transcriptional activation of NME2 expression is a specific and common feature of chronic myeloid leukemia

Leuk Lymphoma. 2012 Aug;53(8):1569-76.   zum Abstract


V. Zuber, A.P. Duarte Silva, K. Strimmer (2012)

A novel algorithm for simultaneous SNP selection in high-dimensional genome-wide association studies

BMC Bioinformatics 2012 Oct 31;13:284.   zum Abstract




M. Horn, I. Glauche, M.C. Müller, R. Hehlmann, A. Hochhaus, M. Loeffler, I. Roeder (2013)

Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia

Blood 2013 Jan 10;121(2):378-84.   zum Abstract


B. Klaus and K. Strimmer (2013)

Signal identification for rare and weak features: higher criticism or false discovery rates?

Biostatistics 2013 Jan;14(1):129-43.   zum Abstract


N. Scherf, C. Ludborzs, K. Thierbach, T. Pompe, I. Glauche und I. Roeder (2013)

panta rhei - a fluid registration approach to cell tracking

Current Medical Imaging Reviews (accepted for publication)


N. Scherf, M. Kunze, K. Thierbach, T. Zerjatke, P. Burek, H. Herre, I. Glauche, I. Roeder (2013)

Assisting the machine - Paradigms for human-machine interaction in single cell tracking

Bildverarbeitung für die Medizin 2013, Informatik aktuell (accepted for publication)


N. Scherf, T. Zerjatke, K. Klemm, I. Glauche, I. Roeder (2013)

Beyond genealogies: mutual information of causal paths to analyse single cell tracking data

Proceedings of the IEEE International Symposium on Biomedical Imaging (ISBI) (in press)


I. Glauche, L. Bystrykh, C. Eaves, I. Roeder (2013)

Stem cell clonality - Theoretical concepts, experimental techniques, and clinical challenges

Blood cell, molecules, and diseases. (in press)


M. Seifert, R. Scholtysik, R. Küppers (2013)

Origin and pathogenesis of B cell lymphomas

Meth. Mol. Biol. 2013;971:1-25.   zum Abstract


N. Walther, A. Ulrich, M. Vockerodt, F. von Bonin, W. Klapper, K. Meyer, S. Eberth, T. Pukrop, R. Spang, L. Trümper, D. Kube (2013)

Aberrant Lymphocyte Enhancer-binding Factor 1 expression is characteristic for sporadic Burkitt lymphoma

Amer. J Pathol. 2013 Jan 30. pii: S0002-9440(13)00022-9.   zum Abstract


Roesch K, Hasenclever D, Scholz M (2013)

Modelling Lymphoma Therapy and Outcome

Bull Math Biol. 2013 Dec 14.  zum Abstract


Rosolowski M, Läuter J, Abramov D, Drexler HG, Hummel M, Klapper W, Macleod RA, Pellissery S, Horn F, Siebert R, Loeffler M. (2013)

Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas

PLoS One. 2013 Nov 4;8(11)  zum Abstract


Zeynalova S, Ziepert M, Scholz M, Schirm S, Zwick C, Pfreundschuh M, Loeffler M; German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) (2013)

Comparison and modelling of pegylated or unpegylated G-CSF schedules in CHOP-14 regimen of elderly patients with aggressive B-cell lymphoma

Ann Hematol. 2013 Dec;92(12):1641-52. zum Abstract


Sibylle Schirm, Christoph Engel, Markus Loeffler, Markus Scholz (2013)

A biomathematical model of human erythropoiesis under erythropoietin and chemotherapy administration

PLOS ONE, Vol. 8 (6)  zum Abstract


Axel Krinner, Ingo Roeder, Markus Loeffler, Markus Scholz (2013)

Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

BMC Syst Biol., Vol. 7 (1), 117-137.  zum Abstract


Schmidt J, Salaverria I, Haake A, Bonzheim I, Adam P, Montes-Moreno S, Piris MA, Fend F, Siebert R, Quintanilla-Martinez L. (2013)

Increasing genomic and epigenomic complexity in the clonal evolution from in situ to manifest t(14;18)-positive follicular lymphoma.

Leukemia; 2013 Oct 23. doi: 10.1038/leu.2013.307.  zum Abstract


Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, Küppers R, Lenze D, Ott G, Pott C, Richter J, Rosenwald A, Szczepanowski M, Schwaenen C, Stein H, Trautmann H, Wessendorf S, Trümper L, Loeffler M, Spang R, Kluin PM, Klapper W, Siebert R. (2013):

Biologic characterization of adult MYC-translocation positive mature B-cell lymphomas other than molecular Burkitt lymphoma.

Haematologica. 2013 Oct 31. [Epub ahead of print].  zum Abstract